Relief Therapeutics Holding AG (RLFTF)

[changes_iv]

Acetylcholine is the chief neurotransmitter of the parasympathetic nervous system, the part of the autonomic nervous system (a branch of the peripheral nervous system) that contracts smooth muscles, dilates blood vessels, increases bodily secretions, and slows heart rate.

https://www.britannica.com/science/acetylcholine

Vasoactive intestinal peptide (VIP) is present in the peripheral and the central nervous systems where it functions as a nonadrenergic, noncholinergic neurotransmitter or neuromodulator. Significant concentrations of VIP are present in the gastrointestinal tract, heart, lungs, thyroid, kidney, urinary bladder, genital organs and the brain. On a molar basis, VIP is 50–100 times more potent than acetylcholine as a vasodilator.

https://academic.oup.com/cardiovascres/article/49/1/27/293330

What Does Norepinephrine Do???

Together with adrenaline, norepinephrine increases heart rate and blood pumping from the heart. It also increases blood pressure and helps break down fat and increase blood sugar levels to provide more energy to the body.

In the brain, norepinephrine plays a role in the sleep-wake cycle, helping you to wake up, in increasing attention and focusing on performing a task ,and in memory storage. It is also important for emotions. Problems with norepinephrine levels are associated with depression, anxiety, post-traumatic stress disorder and substance abuse. Bursts of norepinephrine can lead to euphoria (very happy) feelings but are also linked to panic attacks, elevated blood pressure, and hyperactivity. Low levels can cause lethargy (lack of energy), lack of concentration, attention deficit hyperactivity disorder (ADHD), and possibly depression. Some anti-depressant medications affect norepinephrine levels in the brain.

In stressful situations, norepinephrine increases as part of the fight or flight response to mobilize the brain and body for action.

Norepinephrine can be used to treat low blood pressure (hypotension) that can occur during certain medical procedures or life-threatening situations where cardiopulmonary resuscitation (CPR) is needed.

https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/norepinephrine

In this regard, endogenously released or exogenous VIP can significantly increase the heart rate and has a more potent effect on heart rate than does norepinephrine. The presence and significant cardiovascular effects of VIP in the heart suggests that this peptide is important in the regulation of coronary blood flow, cardiac contraction, and heart rate. Current investigations are defining the physiological role of VIP in the regulation of cardiovascular function.

https://academic.oup.com/cardiovascres/article/49/1/27/293330

The [cardiovascular therapeutics] market is then expected to recover and grow at a CAGR of 3% from 2021 and reach $106.1 billion in 2023.

https://www.thebusinessresearchcompany.com/press-release/global-cardiovascular-drugs-market-data-and-growth-analysis