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Thursday, 02/18/2021 3:29:17 PM

Thursday, February 18, 2021 3:29:17 PM

Post# of 44690
Here is an interesting article that gives some insight into Covid19 mutant variants. One of the take home points is the fact that there are 2 key mutations: mutation (N501Y) known to help the virus bind more tightly to human cells and another mutation (E484K) known to help the virus evade antibody detection. Also, laboratory experiments have shown that some of those mutations help the virus bypass detection by antibodies. (Side note: the patient was treated with Regeneron monoclonal antibodies and researches saw evidence that the virus was developing resistance or escaping the antibodies)

https://www.npr.org/sections/goatsandsoda/2021/02/05/964447070/where-did-the-coronavirus-variants-come-from

Now take a look at this article which uses a molecular computational approach to study the binding site of Aviptadil on SARS-CoV-2 nsp16/nsp10 complex which is necessary for the effective translation of coronavirus RNA and which is also essential for preventing immune recognition.
“Inhibitory effects of aviptadil on the SARS-CoV-2 nsp10/ nsp16 protein complex”

https://www.researchsquare.com/article/rs-191980/v1

Nothing is known for certain but this definitely helps reinforce my confidence in Aviptadil. IMO / GLTA