General Stock Ideas

[gfp927z]

Bigworld, The stock I mentioned (IPIX) is moving up as expected, at least so far. Their drug Brilacidin was originally developed at the Univ of Penn as a broad spectrum antibiotic with a totally unique mechanism. The approach is called HDP-mimetics, and it mimics the oldest biological defense system - host defense proteins. This has phenomenal potential against both bacteria and viruses.

Years ago their Phase 2 against MRSA was amazingly successful, but mismanagement of the company led it to being taken over by IPIX (then called Cellceutix), who had other clinical priorities. But with the appearance of Covid, the drug (Brilacidin) underwent quasi government testing (U.S. Regional Biocontainment Laboratory) and had phenomenal in-vitro activity against Covid. Brilacidn subsequently received Fast Track Designation from the FDA, and last week the company announced the Phase 2 (120 patients) would start this week. The stock has started to take off, but market cap still only $140 mil.

Anyway, this is definitely one to watch (I have 50,000 shares, avg cost of .23 cents). I followed Brilacidin in the early days (~2012), and kept it on my radar, figuring the vast potential might some day be realized.

One big plus with the defensin mimetic approach is the extreme unlikelihood of resistance ever developing to the drug. The mechanism works directly at the cell wall, instead of via inhibiting the internal cellular machinery or DNA. Pores/holes form on the cell wall which kills the virus or bacteria, which is the same mechanism used by the body's own innate defense protein system. It should also work on the various mutated forms of Covid, and potentially be a broad spectrum 'pan-coronavirus' therapeutic. Check it out -


https://en.wikipedia.org/wiki/Brilacidin#The_HDP-mimetic_pipeline

http://www.ipharminc.com/