Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

IPIX receives 6% of any revenue.I can not locate the reference,but as I recall pre clinical screening showed the Polymedix anti fungal showed defensin mimetic was active against Canida Albicans and perhaps C auris.

I did find this:

"In a poster titled, "Activity of an Antifungal Peptide Mimetic in an Experimental In Vivo Model of Oral Candidiasis," Dr. Scott presented data describing the anti-fungal activity of PolyMedix's defensin-mimetic compounds. This presentation described a series of compounds that are potently active and highly selective for the Candida fungal pathogen over other bacterial and eukaryotic cell types. The compounds appear to kill C. albicans by rapidly permeabilizing its cell membrane, similar to the mechanism of action of other defensin-mimetic compounds in killing bacteria. The activity of a lead compound, PMX-519 was examined in an oral model of Candida infection in mice. Mice were treated with a single topical application of drug three days after infection of the oral cavity with C. albicans. The results showed that PMX-519 produced near total sterilization of the infected tongue following the single administration, and was 50-fold more effective than nystatin, a commonly used anti-fungal agent. This work was supported under a Phase 2 SBIR grant received from the National Institute of Health (NIH)."

http://www.biotechinvest.net/pymx_arch.html