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Re: KDOG9 post# 24448

Tuesday, 01/19/2021 7:40:22 PM

Tuesday, January 19, 2021 7:40:22 PM

Post# of 42562
They changed it to ventilator free survival at 28 days.

I interpret this as quite a bit of confidence that lenzilumab deters progression to ventilation. After all, the p value on that exact endpoint was 0.06 in the case control trial (though only out to 18 days, but I would argue you far more likely to lose more in the control group over days 19-28 than the lenzilumab group), and that was a *TINY* study!

If you extrapolate that out over 500+, the p value is likely to be way way lower than 0.05. In other words, that would mean the primary endpoint hits.

This is all good to me.