Humanigen Inc (HGENQ)

[ohm20]

From a post I made in early October.

From a medical paper -

Ang II can activate the nuclear factor kappa B (NF-?B) pathway [24], [25] via stimulation of the phosphorylation of the p65 subunit of NF-?B [26]. This will lead to increased production of IL-6 [27], TNFa, IL-1B and IL-10 [26]. After AT1R activation, Ang II regulates Mitogen-Activated Protein Kinases (MAPK) (ERK1/2, JNK, p38MAPK), which have important functions on cellular processes including the release of cytokines such as IL-1, IL-10, IL-12 and TNFa

My response which shows downregulation of NF-kb and as shown from the paper it would lead to downregulation of IL-10 -

CCR5 blockade disrupts the PI3K,mTOR / 4E-BP1 via downregulation of NF-kb. The same disrupted pathway I proposed for **********'s possible ability to act as a direct antiviral. CCR5 blockade also downregulates MAPK, ERK 1 and 2, JAK1 and 2, JNK (MAPK 8-10) and TNF-a.