Wednesday, December 16, 2020 1:17:30 AM
GM-CSF affects a part of the equation in COVID-19. CCR5 blockade breaks down a myriad of feedback loops.
https://www.nature.com/articles/srep30802
One of the pathways for CCR5 downregulation of GM-CSF.
Downregulation of IL-4 as shown above. IL-4 increases IFN-y, reduction of IL-4 decreases IFN-y
https://ashpublications.org/blood/article/102/1/207/16816/IL-4-synergistically-enhances-both-IL-2-and-IL-12
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795790/
IL-33 is responsible for upregulation of GM-CSF.
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30340-4/fulltext#seccestitle50
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