MultiCell Technologies Inc (MCET)

[TPX]

More accurate Granted Patent Drug names are called: IFH15, IFHP.06, IFHP.12, IFHP.24, IFHP.48, IFHP.96 ( CYP1A2, CYP2B6, CYP2C9, CYP3A4! Multicell Technologies Immortalized Hepatocytes Doc Type Granted Patent in US, Europe and Germany! )

https://www.xenotech.com/in-vitro-test-systems/cell-products/primary-human-hepatocytes/plateable/immortalized/

Our Fa2N-4 Cell Line
The use of fresh human hepatocytes can be problematic due to unpredictable availability, limited supply, and donor-dependent variability in performance. The solution is an immortalized, ready-to-use cell line that is proven to perform well for many in vitro drug development applications.

We offer access to cells from the Fa2N-4 immortalized human hepatocyte cell line, which is useful to evaluate the induction of major cytochrome P450s (CYPs), UDP-glucuronosyltransferases (UGTs), and P-gp, and are a suitable test system for CYP induction screening and lysosomal sequestration/trapping.

Please note that the passaging of these cells is not allowed without a license agreement.

Cell Line Information
The Fa2N-4 cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.
https://www.xenotech.com/wp-content/uploads/2020/03/Fa2N-4-Lot-1910093-with-Supplement-A.pdf