Long run on MRNA and the other vaccine makers, I think the extreme refrigeration needed is going to be a hindrance to high usage. I think that's why they applied for early approval. They need to get a head start because if more vaccines report results that don't require more than refrigerator temps and definitely low costs, they are going to get snapped up by the market. At first all will flourish because the whole world needs vaccines but once the mad rush is over, the market will favor ease of use and low cost.
Once mass innoculations begin, there may be other factors that affect usage but this temperature thing seems important to me.
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