Friday, November 20, 2020 2:02:41 PM
Living human lung air sacs in tiny dishes promise to accelerate Covid research
Baric’s lab is capable of changing any nucleotide of the Covid-19 virus’s genetic code at will, so it produced a glowing version that would reveal where it went in the mini-lungs, confirming that it did indeed home in on the crucial ACE2 cell surface receptor, leading to infection.
When infected with the virus, the organoids were shown to launch an inflammatory response mediated by interferons. The researchers have also witnessed the cytokine storm of immune molecules the lungs launch in response to the virus.
“It was thought cytokine storm happened due to the large influx of immune cells, but we can see it also happens in the lung stem cells themselves,” Tata said.
https://today.duke.edu/2020/10/lab-grown-mini-lungs-mimic-real-thing-%E2%80%93-right-down-covid-infection#.X7gRZbQCsio.twitter
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