Biotech Values

[OakesCS]

the freezing point depression of any aqueous solution i'd consider to be reasonable for injection will be >> -70 degC so even if the shipped vaccine contained 'free' H2O the mixture would be solid. Solids can still hydrolyze thru vapor phase but at those temperatures the amount of H2O would be so small that i cant imagine that it would be significant. Solid-solid hydrolysis reaction rates must be geologic at those temps.

Dewophile mentioned that jbog said the shipped formulation would be freeze-dried so the above is probably moot.

Around surface temps reaction rates tend to ~double with each 10 degC increase. I'm not sure if that is still true near -70 degC. If it is and the vaccine stability is simply temperature dependent, then something in the vaccine has some very fragile bonds and thus my question. If the vaccine is so fragile that it's viability is only days at -56 degC, then i'm amazed it lasts more than minutes once it's dispersed in a liquid for injection.