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Tuesday, November 03, 2020 9:21:56 AM
Many question the ethics of using a placebo when studying a life threatening illness.
"But it’s not so easy to determine how those participants should—and shouldn’t—receive treatment. “Most people believe a placebo is necessary for a gold-standard trial,” says Li. In the strictest sense, a placebo would be nothing more than a sugar pill, as this allows scientists to determine whether the treatment under study is actively helping people.
The ethics of a true placebo don’t pan out in a pandemic situation: When patients are suffering from a serious medical condition, doctors use “standard care” as the placebo instead. “Since most new drugs don’t work or are harmful, you are not clearly worse off by being randomized to a placebo on top of usual care,” says Alex John London, director of the Center for Ethics and Policy at Carnegie Mellon University, who has written on the ethics of clinical research during public health emergencies.
For Covid-19, standard care is largely supportive. The lopinavir–ritonavir study tested the drug against giving patients oxygen, ventilation, antibiotics, and support for pumping blood, kidney function, and blood pressure as needed. Researchers can also run “adaptive trials,” meaning they test various drugs against each other, as well as as combining the drugs to see if that increases
effectiveness. The format allows for certain drug treatments to be abandoned more quickly if it seems to be ineffective, and also allow more patients to have access to potentially effective treatments. But it can take longer to prove that a drug is effective when compared to another drug, as opposed to when it’s compared to placebo alone."
https://qz.com/1826431/the-ethics-of-clinical-trials-for-coronavirus-treatments/
GLTA Farrel
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