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Monday, October 26, 2020 1:17:11 PM
- A high-throughput microfluidic nano-immunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultra-low volume dried blood sample.
There is therefore a clear need for new technologies to supersede existing methods such as ELISA, 36 CLIA, and LFAs. Novel technologies should be capable of high-throughput, low-reagent consumption, low37 cost per test, high sensitivity and specificity, and be compatible with ultra-low volume whole-blood samples 38 in the low or even sub-microliter range that can be obtained via a simple fingerprick. Biomarker detection 39 using dried whole blood on filter paper or other devices would have tremendous advantages as it can be 40 collected by untrained individuals at home. The samples could then be conveniently shipped by regular 41 mail at ambient temperature to a central laboratory for analysis and test results returned electronically via a 42 mobile app or email.
Microarray spotting 336 25 µL of each sample were loaded into a 384 microwell plate (ArrayIt, MMP384). An MP3 microarray 337 printing pin (Arrayit) was used to spot the samples onto an epoxy-coated glass slide using a QArray2 mi338 croarrayer (Genetix). The presence of Triton X-100 in the serum samples had a significant effect on the spot 339 diameter. To account for this we increased the dimensions of the spotting chamber and set the inking and 340 stamping time to 50 ms and 1 ms, respectively. In addition, it was critical that the ambient humidity was 341 below ~42%, otherwise the spots would become too large and merge together. After spotting, the PDMS chip was aligned on top of the sample spots using a stereo microscope and bonded over night at 40 ? 342 C....
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https://www.medrxiv.org/content/10.1101/2020.10.07.20208280v2.full.pdf
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