Relief Therapeutics Holding AG (RLFTF)

[mchammertime]

RLF-100 vs REMDESIVIR....WOW!

thought I would look again at the data from Remdesivir that got them the EUA. They have always centered on rate of recovery but at the end they show they only had 4.8% reduction in mortality rate, but if you lived you recovered 4-5 days earlier.

Time to Recovery (all patients)
VEKLURY(remdesivir)10 days
Placebo 15 days

(recovery rate ratio: 1.29 [95% CI, 1.12-1.49]; p<0.001)
The odds of improvement in the ordinal scale were higher in the VEKLURY group at Day 15 when compared to the placebo group (odds ratio: 1.6 [95% CI, 1.3-1.9]; p<0.001).
Among subjects with mild/moderate disease at enrollment (n=105), the median time to recovery was 5 days in both the VEKLURY and placebo groups (recovery rate ratio: 1.22 [95% CI, 0.82-1.81]); the odds of improvement in the ordinal scale in the VEKLURY group at Day 15 when compared to the placebo group were as follows: odds ratio: 1.46 [95% CI, 0.71-2.97].
Among subjects with severe disease at enrollment (n=957), the median time to recovery was 11 days in the VEKLURY group compared to 18 days in the placebo group (recovery rate ratio: 1.31 [95% CI, 1.12-1.52]; p<0.001); the odds of improvement in the ordinal scale in the VEKLURY group at Day 15 when compared to the placebo group were as follows: odds ratio: 1.56 [95% CI, 1.24-1.95].

Here is the end mortality rate reduction: it helped 4.8%!!!!!

Mortality (interim analysis*)
14-Day Mortality Rate (all patients)
VEKLURY 7.1%
Placebo 11.9%