Relief Therapeutics Holding AG (RLFTF)

[J-Belfort]

Just the beginning of what is to come

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DD post by: Mount Pilatus (Another Board)

https://patents.google.com/patent/US8178489

Example 6
The following provides clinical examples for drug dosages, safety and efficacy for inhaled administration by chronically ill patients of the medicament formulation at pH values between 5.3-6.0.

Post-VSD

A patient suffering from pulmonary hypertension associated to post-ventricular septal defect (post-VSD) inhaled 100 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 21% in pulmonary vascular resistance consisting of an increase of cardiac output and decrease of mean arterial pulmonary pressure, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 400 micrograms split into 4 single dosages of 100 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 2800 micrograms Aviptadil.

IPAH

A patient suffering from idiopathic pulmonary arterial hypertension (IPAH) inhaled 100 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 20% in pulmonary vascular resistance consisting of an increase of cardiac output and decrease of mean arterial pulmonary pressure, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 400 micrograms in 4 single dosages of 100 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 2800 micrograms Aviptadil.

CREST Syndrome

A patient suffering from pulmonary hypertension associated to scleroderma (CREST syndrome—Calcinosis; Raynaud's disease; loss of muscle control of the Esophagus; Sclerodactyly; Telangiectasia) inhaled 100 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 14% in pulmonary vascular resistance mainly consisting of an increase of cardiac output, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 400 micrograms split in 4 single dosages of 100 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 2800 micrograms Aviptadil.

Extrinsic Allergic Alveolitis

A patient suffering from pulmonary hypertension associated with extrinsic allergic alveolitis inhaled 100 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 21% in pulmonary vascular resistance consisting of an increase of cardiac output and decrease of mean arterial pulmonary pressure, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 400 micrograms in 4 single dosages of 100 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 2800 micrograms Aviptadil.

Chronic Obstructive Pulmonary Disease

A patient suffering from pulmonary hypertension associated to chronic obstructive pulmonary disease inhaled 100 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 20% in pulmonary vascular resistance consisting of an decrease of mean arterial pulmonary pressure, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 400 micrograms in 4 single dosages of 100 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 2800 micrograms Aviptadil.

A patient suffering from pulmonary hypertension associated to chronic obstructive pulmonary disease inhaled 200 micrograms of Aviptadil as a single dose without any irritation of the lungs. The efficacy of the medicament is demonstrated by a decrease of 25% in pulmonary vascular resistance consisting of an increase of cardiac output and decrease of mean arterial pulmonary pressure, while having no systemic side effects, and as compared to the patient's baseline characteristics. The daily dose for that patient comprises 800 micrograms in 4 single dosages of 200 micrograms of Aviptadil each. Thus a weekly dosage for such a patient is 5600 micrograms Aviptadil.

Example 7
The following provides clinical examples for drug dosages, safety and efficacy for infused administration of the medicament formulation at pH values between 5.3-6.0 for patients with acute life threatening conditions like respiratory distress syndrome due to sepsis, burns, gas intoxications, and ischemia.
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There are even more historical examples of Aviptadil being used and tested for a wide array of ailments (if you look and read). I suppose some get overly excited over television stories such as the one @chris on that other board posted this AM, for their RLFTF information as opposed to true DD on RLFTF which requires reading....

JB