Monday, September 28, 2020 8:47:37 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905176/
ABSTRACT
We investigated the effects of bucillamine and N-acetyl-l-cysteine (NAC) on cytokine production and CIA. Bucillamine and NAC inhibited NF-?B activation and tumour necrosis factor-alpha (TNF-a) mRNA expression in human monocytic leukaemia cell line THP-1, and cytokine production from monocyte cell lines at concentrations >10-3 m. They also inhibited cytokine production and CIA in mice at a dose of 500 mg/kg. These results suggest that NF-?B inhibitors such as bucillamine and NAC may inhibit cytokine-related diseases, including arthritis.
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