Nascent Biotech Inc. (NBIO)

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9/9/20 - Excited to share our review article on the life of vimentin - inside and outside the cell! Mechanical and Non-mechanical functions of filamentous and non-filamentous vimentin:

https://twitter.com/PattesonLab/status/1303735403061669888/photo/1

9/6/20 - 5 Conclusion
The striking viscoelastic properties of VIF networks in vitro suggest cellular functions based on resistance to mechanical stress and regulation of cell shape. Indeed VIFs are essential for protection of the nucleus from potentially damaging forces and forms much of the cytoskeleton. However, many studies point to important non-mechanical functions. Vimentin, either in the form of small oligomers or VIFs, binds numerous proteins and nucleic acids, and functions to integrate with other cytoskeletal systems, regulate lipid metabolism and perform numerous other intracellular functions. In addition, the rapidly growing study of extracellular vimentin, especially in the regulated disassembly of VIF and the secretion of modified vimentin, reveals many new functions for the protein, from mediating pathogen invasion to promoting wound healing. Clearly there is much more to be learned about this abundant but understudied protein.

https://onlinelibrary.wiley.com/doi/full/10.1002/bies.202000078