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Re: None

Thursday, 09/17/2020 8:05:18 PM

Thursday, September 17, 2020 8:05:18 PM

Post# of 251702
Quick comparison of PFE/BNTX, MRNA protocols:

• PFE/BNTX has four interim looks (at 32, 62, 92, and 120 events); MRNA has two interim looks (at 53 and 106 events).

• PFE/BNTX has the final analysis at 164 events; MRNA has the final analysis at 151 events.

• PFE/BNTX has futility tests at the first three interim looks; MRNA does not have any futility tests.

• The definition of an “event” is slightly different in the two protocols (but probably not different enough to matter from a practical standpoint).

PFE/BNTX protocol (see p.103):
https://t.co/w0TU1yVe7T?amp=1

MRNA protocol (see p.98):
(https://t.co/The04HDHmE?amp=1

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