Innovation Pharmaceuticals Inc (IPIX)

[thefamilyman]

Lemoncat said,

In animal testing the drug has to prove that its delivery mechanism works in a system that somewhat resembles a human system...vessels, membranes, pumps, etc.

Gee! I wonder why the FDA is not making Brilacidin go back and do some more animal trials? Could it be that Brilacidin has already proven that it’s “delivery mechanism works”...in actual humans? You know I do seem to recall that in the Phase 2 trial for ABSSSI, one thing that Brilacidin proved was that “its delivery mechanism works in a system that somewhat resembles a human system...vessels, membranes, pumps, etc.” Oh wait! Those patients in the ABSSSI trial didn’t just resemble a human system, they WERE human systems, hundreds of them in fact! And Brilacidin worked GREAT!

Lemoncat said,

In vivo testing is almost always a superior standard of efficacy test than in vitro. Does it always work? No, of course not - Prurisol is a shining example of that.

You are still wrong and “Prurisol IS a shiny example of that.” The mice in the Prurisol trial were even genetically engineered to better reflect human tissue. But while Prurisol worked well for the mice, it did not work in humans.

In the case at hand, we already know from previous trials that Brilacidin’s “delivery mechanism works” in the actual human system. We also know that it kills the virus in human cells at rates approaching 100%. Do you really think that a few tests on animals means that Ab8 is somehow ahead of Brilacidin in the race to prove efficacy in humans? Sorry, but you are just sooo wrong...

Oh, and I know safety is not something you like to focus on, but remember; Brilacidin has been proven to be safe in humans with an SI Rating for Covid of >300. Ab8 has not been proven safe in humans and does it even have an SI Rating for anything? Oh well, one of those articles did mention that they had more animal testing to do before they could talk to the FDA about human testing.