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Effect of a novel extracorporeal cytokine apheresis method on endocan, copeptin And interleukin-6 levels in sepsis: An observational prospective study
Berna Kaya Ugur et al. Transfus Apher Sci. 2020.
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Transfus Apher Sci
. 2020 Aug 25;102919.
doi: 10.1016/j.transci.2020.102919. Online ahead of print.
Authors
Berna Kaya Ugur 1 , Hülya Çiçek 2 , Seval Kul 3 , Özlem Mete 4 , Mehmet Yilmaz 5
Affiliations
1 Gaziantep University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Gaziantep, Turkey. Electronic address: bernakayaugur@hotmail.com.
2 Gaziantep University, Faculty of Medicine, Department of Biochemistry, Gaziantep, Turkey. Electronic address: drhulyacicek@hotmail.com.
3 Gaziantep University, Faculty of Medicine, Department of Biostatistics, Gaziantep, Turkey. Electronic address: sevalkul@yahoo.com.
4 Gaziantep University, Faculty of Medicine, Department of Infectious Diseases, Gaziantep, Turkey. Electronic address: ayseozlem_ornek@hotmail.com.
5 Sanko University, Faculty of Medicine, Department of Hematology and Internal Medicine, Gaziantep, Turkey. Electronic address: mmyilmaz246@hotmail.com.
PMID: 32912735
DOI: 10.1016/j.transci.2020.102919
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Abstract
Purpose: There is still an evident need for useful biomarkers and effective therapeutic approaches regarding the challenging management of sepsis. The aim of the study is to evaluate the effect of each Cytosorb hemoadsorption therapy course on blood levels of inflammatory biomarkers of sepsis including endocan, copeptin, interleukin-6, procalcitonin, C-reactive protein.
Methods: There were a total of 178 samples belonging to 34 patients that were diagnosed with sepsis and undergone Cytosorb therapy during the study period. Patient demographics were recorded. Arterial blood samples were obtained both before and and after each Cytosorb course. Levels of copeptin, interleukin-6, procalcitonin, C-reactive protein, erythrocyte sedimentation rate, white blood cell count, and creatinine were assessed both before and after each Cytosorb treatment.
Results: Levels of endocan, copeptin, interleukin-6, procalcitonin, C-reactive protein, and erythrocyte sedimentation rate were all significantly decreased after the Cytosorb course when compared with levels before therapy (p = 0.039, 0.001, 0.010, 0.001, 0.002 and 0.001, respectively). There was no significant difference between white blood cell count and creatinine levels before and after Cytosorb courses (p = 0.204 and 0.277).
Conclusion: Cytosorb courses achieved significant decreases in endocan, copeptin, interleukin-6, procalcitonin and C-reactive protein levels. Decreasing plasma levels of inflammatory cytokines may help alleviate the cytokine storm and may have a role in improve outcomes. Further prospective randomized controlled studies with larger sample size are needed concerning the long-term effects of this decrease in cytokine levels on outcome and mortality.
Keywords: Copeptin; Cytosorb; Endocan; Interleukin-6; Sepsis.
