Relief Therapeutics Holding AG (RLFTF)

[changes_iv]

A growing body of experimental evidence indicates that surfactant dysfunction may contribute to the airway obstruction of asthma. In fact, guinea pigs sensitized with ovalbumin and then challenged by aerosol exhibit altered performance of surfactant (2). Similarly, lung lavage fluid and sputum of patients with allergic asthma contain a surfactant with decreased surface activity (3, 4). Leakage of plasma proteins into the airways appears to play a fundamental role in surfactant inactivation (3, 5). Other invoked mechanisms include increased hydrolysis of surfactant phospholipids (6) and decreased synthesis of hydrophobic surfactant proteins (7).
https://www.atsjournals.org/doi/full/10.1164/rccm.2312019
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Surfactant and allergic airway inflammation

https://smw.ch/article/doi/smw.2013.13818