Cytodyn Inc (CYDY): But bradykinin does nothing unless it bi...

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Re: ssbains post# 116328

Monday, 09/14/2020 4:24:50 AM

Monday, September 14, 2020 4:24:50 AM

But bradykinin does nothing unless it binds to one of its receptors. Far less BR1 with CCR5 blockade and when it binds to BR2 it's acts as an anti-inflammatory.

Bradykinin is also elevated with lack of degradation from ar1 downregulation. It is very independent of ccr5.

TNF-alpha and IFN-gamma (both downregulated by CCR5 blockade) are responsible for upregulating the kinin B1 receptor which is where bradykinin binds. So bradykinin is CCR5 dependent.

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