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Tuesday, September 01, 2020 3:40:23 AM
From USPTO Patent # US8178489B2
Title: Formulation for aviptadil
Inventors: Gerald Bacher, Dorian Bevec
Abstract
The present invention relates to pharmaceutical formulations of Aviptadil and its derivatives. The stability of the Aviptadil formulation was shown to be improved by a formulation having a defined concentration of Aviptadil prepared in a buffer having a defined pH range.Claims:
1. A liquid, pharmaceutical formulation comprising 0.001 to 1.0% (w/v) Aviptadil in a buffer, wherein said buffer maintains the pH of the formulation at a pH of 4.8 to 6.7.
2. The liquid, pharmaceutical formulation of claim 1 which is substantially isotonic.
3. The liquid, pharmaceutical formulation of claim 2 which further comprises as stabilizer about 1% to about 10% a carbohydrate or a polyhydric alcohol.
4. The liquid, pharmaceutical formulation of claim 2 which further comprises a preservative.
...
20...."
And having a "defined concentration" begins stabilization of the peptide!
In words that I heard from the Director of the Patent Office of India, "You could take a piece of paper, fold it up in a new way, and the US Patent Office would grant you a patent for it." (para)
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