IVERIC bio, Inc. (ISEE)

[Fezziwig2008]

$ISEE
Zimura as a Rx of Wet AMD with Lucentis-
“All 4 groups achieved significant gains in visual acuity at 6 months, defined as gaining greater than or equal to 3 lines of vision, or 15 ETDRS letters. The group with the highest percentage of patients achieving significant visual acuity gains (60%) was the group that received .5 mg of Lucentis and 2 mg of Zimura on the same day. This was the same dosing group that achieved the highest success rates in the previous 1/2a trial of Zimura. Other dosing groups had the 2 drugs staggered or had the 2 drugs in combination with a follow-up dose of Zimura only at 2 weeks.” *

so 2 points- 1. It helps explain why Wet AMD is 1/2 as common with
$ISEE
Zimura than with
$APLS
Pegcetacoplan.
2.
$AGN
needs a new Wet AMD treatmeNT- makes
$ISEE
a more likely target for GA, Wet AMD, and Gene therapy.



* https://www.hcplive.com/view/zimura-lucentis-combo-safe-but-company-decides-not-to-move-forward