electroCore, Inc. (ECOR)

[Fezziwig2008]

ECOR Gammacore reduces Lung Inflammation by releasing Acetylcholine in Viral Disease:
Vagal stimulation releases its neurotransmitter acetylcholine (ACh) https://res.mdpi.com/d_attachment/ijms/ijms-19-02466/article_deploy/ijms-19-02466.pdf -it’s receptor -a7nAchR’s -agonist decreased the pulmonary LPS-induced inflammatory response and reversed the inflammatory profile, particularly regarding M1 and M2 polarization, while also improving lung function and remodeling in a model of acute lung injury Based on these findings and those in the current study, we hypothesize that ACh produced by cholinergic lymphocytes acts on macrophages to decrease pro-inflammatory cytokine release and initiate tissue repair during the recovery phase of respiratory viral infection.
https://scholar.google.com.hk/scholar?as_ylo=2016&q=vagal+stimulation+an