Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

Your numbers are a little high:
Phase 2a ABSSSI trial: BRI Low dose: 1.60 mg/kg over 5 days BRI Med. dose: 2.15 mg/kg over 5 days BRI High dose: 2.40 mg/kg over 5 days

Total 5 day average dose ranged from ~128 mg To ~172 mg. There were side effects and toxicity.

Phase 2b ABSSSI there was a substantial reduction in dosage and an increase in efficacy with almost no side effects.

.6 mg/kg and .8 mg/kg for one day each. There was a 3 day arm at .6 mg/kg per day, but that showed no improvement over the one shot and done, one day course arms. Total IV administered was average ~48 mg and ~64 mg, respectively.

https://static1.squarespace.com/static/5715352e20c647639137f992/t/583f8286d2b85731b8713a36/1480557192947/A-Randomized-Double-Blind-Study-Comparing-Single-Dose-and-Short-Course-Brilacidin-to-Daptomycin-in-the-Treatment-of-Acute-Bacterial-Skin-Skin-Structure-Infections-ABSSSI1.pdf