Generex Biotechnology Corp. (fka GNBTQ)

[WeeZuhl]

Question for this message board concerning other vaccines such as Moderna's.

Not sure if I heard this right, but according to a source I contacted these other vaccines have limited immuno "memory" which may possibly go out to about 2 years or so if that.....

I read there are currently more than 120 COVID-19 vaccines in development, and the only way to tell if they provide lasting immunity is try them out. That's why it typically takes 4-5 years to develop and test a vaccine. Probably every one of the 120 has an argument for why they are building the better mousetrap.

Moderna's whole existence is based on rapid development of vaccines for emerging diseases. Their vaccine is a package of mRNA delivered in a lipid envelope. mRNA is the actual working-copy of a gene that cellular machinery uses to make peptides, which are folded together to make new proteins and enzymes. Moderna sneaks in a bunch of mRNA that encodes portions of the viral spike protein, so now the cells start manufacturing fake spike protein peptides. Moderna has proven that the human immune system recognizes these fake spike peptides as foreign and then develops an antibody response. They have not yet proven their vaccine provides immunity to COVID, either transient or long-term. They have not proven long-term safety.

Antigen Express utilizes a peptide vaccine. They used computer modeling to predict which portions of the spike protein are most likely to trigger a strong human immune response (EpiVax collaboration), and then they joined the computer-generated fake spike peptide with their proprietary Ii-key peptide. The addition of the Ii-key peptide is what makes our vaccine unique from any other. The Ii-key peptide is like a silver platter for the fake spike peptide. It draws the attention of specialized immune cells, called helper t cells. If I were a t cell, I would want to be a helper t cell. They tell all the other immune cells what to do. Killer t cells act tough, but helper t cells run the show. Ii-key peptide activates helper t cells, and theoretically, results in a stronger vaccine response. That's our whole bet.

Odds are that the first vaccine to finish Phase 3 will not be the best vaccine. You don't have to be the first to be the best, but you do have to be on the same lap.