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Thursday, July 23, 2020 6:16:17 AM
Shares of the company have increased 20.5% year to date compared with the industry’s growth of 10.6%.
Tizona develops first-in-class medicines to bring in transformations for people suffering from cancer. Its lead pipeline candidate is TTX-080. TTX-080 is a potential first-in-class medicine that targets HLA-G. The characteristic of HLA-G is that it can address tumors that do not respond to current anti-PD-(L)1 treatments. It also deepens responses in tumors that are sensitive to anti-PD-(L)1 therapies.
However, Gilead can exercise this option to acquire the remainder of Tizona following the readout of a phase Ib study of the latter’s investigational antibody, TTX-080, or earlier, if the former decides to do so.
The investigational new drug (IND) application for TTX-080 has been cleared by the FDA. Tizona plans to initiate a phase I study evaluating TTX-080 both as a monotherapy and in combination with other agents in patients with advanced cancers.
Gilead will have the right to appoint two individuals to Tizona's board of directors upon the closing of the transaction. The deal is expected to close in the third quarter of 2020.
Tizona's investigational first-in-class anti-CD39 antibody, TTX-030, developed in partnership with AbbVie ABBV, will be divested before the closing of this transaction. TTX-030 is not part of this agreement.
By acquiring a stake in Tizona, Gilead plans to build a strong and diverse immuno-oncology pipeline as the former is developing first-in-class cancer immunotherapies that address tumors that do not respond to current checkpoint inhibitors. Thus, this could be an excellent opportunity for Gilead to develop novel therapies that will improve the treatment of cancer.
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