electroCore, Inc. (ECOR)

[Fezziwig2008]

ECOR explained: Recent Findings- Vagus Nerve: The Key Integrator of Anti-inflammatory Reflex

“Understanding of these components of vagal anti-inflammatory reflex pathways has therapeutic implications, since they could be targeted in various means to stimulate anti-inflammatory regulation in TNFa- related diseases such as inflammatory bowel disease and rheumatoid arthritis. The vagal nerve stimulation, either as an invasive or non- invasive procedure, is becoming increasingly the objective of many researches to evaluate the potential effectiveness of vagus nerve stimula- tion (VNS) to alleviate chronic inflammation. As such VNS has recently been attempted in the management of many clinical disorders:

The recent discovery that cholinergic neurons inhibit acute inflammation has facilitated our understanding of how the ANS moderates immune responses. Recent studies have identified a basic neural pathway that reflexively monitors and inhibits inflammatory response. Therefore, the activation of anti-inflammatory responses has collectively been termed as anti-inflammatory reflex. Inflammatory stimuli activate sensory pathways that relay information to the hypothalamus, which integrates and mobilizes defences to eliminate the inflammation.”
View at ijcep.phcog.interactivedns.com