Humanigen Inc (HGENQ)

[Fezziwig2008]

HGEN Targets Correct COVID Target -GM-CSF - “Itwas reported that the percentages of GM-CSF-expressing CD4+ T cells, CD8+ T cells, natural killer cells and B cells were significantly higher in the blood of patients with COVID-19 who were admitted to an intensive care unit (ICU) than in healthy controls1. This pan-cellular observation was not seen with IL-6 and TNF expression in the respective populations. We, along with others1,72, suggest that in patients with COVID-19, dysregulated GM-CSF expression could induce overactivation of myeloid cells that secrete pro-inflammatory mediators and destructively infiltrate tissue, such as the lungs and potentially even the heart and the nervous system. This suggestion is consistent with the disease-driving mechanism of action of GM-CSF proposed in many preclinical models with pathologies similar to that of late stages of COVID-19” https://www.nature.com/articles/s41577-020-0357-7?elqTrackId=801873428fb148a9b448f36eae558b8b