Innovation Pharmaceuticals Inc (IPIX)

[MinnieM]

I suspect the company will be filing for numerous grants once all lab testing done. But, I'm happy to see one of the labs has already filed one in collaboration with the company. This will likely be a small one. They seem to get larger with additional grants.

The company has backed off vaccine testing until a later time. The focus of current testing at the two US RBL's is for therapeutic usage.

From May 19, 2020 http://www.ipharminc.com/press-release/2020/5/19/innovation-pharmaceuticals-brilacidin-reduces-viral-titer-of-sars-cov-2-covid-19-by-75-percent-after-only-1-hour-of-preincubation-in-in-vitro-study-at-bsl-3-facility

"Separately, the Company and laboratory researchers (from a different testing facility) agreed that Brilacidin as a vaccine would not be studied further at this time. While the vaccine pathway remains of interest, the Company is prioritizing Brilacidin’s clinical development as a potential novel COVID-19 treatment, and thus is taking steps to rapidly advance Brilacidin into human trials."

It's great to see that two different US RBL's are testing Brialacidin for therapeutic usage in covid since the drug has already been tested in clinical trials. That puts us a step ahead of many others.

Aside from Covid, Brilacidin has passed safety benchmarks in multiple clinical trials:

Brilacidin for ABSSSI is ph3 ready. Ph2 was dosed via IV in hundreds of patients.

Brilacidin for OM is ph3 ready. Ph2 was dosed via swish and spit.

Brilacidin for UP ph 2 POC trial was dosed with water enema. Results good enough that Alfasigma licensed Brilacidin for UP dosing with foam, enema, or gel.

Brilacidin for UC ph 1 was dosed with Oralogic tablets.

Covid related isn't the only thing we could hear news on.

I'm still expecting something to happen with Brilacidin OM. Hopefully, not until after Covid testing is done so that a better deal can be negotiated if success shown in more covid tests.

We are still waiting on next move in UC.

And, we may yet hear more about UP from Alfasigma.

I highly doubt we'll be revisiting Brilacidan as a vaccine due to the time involved. And, I'm delighted on the good info we've seen thus far relating to a potential Covid therapeutic.





Message in reply to:

Is there a possibility for a 3rd grant?


One for B IV in clinical trial...one for production of B IV and one for....vaccine


A vaccine based on Brilacidin, a defensin-mimetic, is another potential clinical development pathway, though developing Brilacidin as a vaccine would involve a longer process (12-18 months) than advancing it as a COVID-19 drug candidate. Legislative and regulatory authorities, however, have indicated (pdf) a willingness to expedite vaccine development, including eliminating the need for animal studies, assigning promising vaccines Breakthrough Therapy status and making COVID- 19 vaccines eligible for Priority Review Vouchers, etc. Information below and posted to the Company website includes links to literature detailing the potential of defensins developed as antiviral vaccines.