Saturday, July 11, 2020 11:37:54 AM
•Function of heat shock protein gp96:
- Potent mucosal adaptive memory inducer
- Chaperones antigens (pathogens or tumor) to the immune
system
- Activates B cell response and drives antigen-specific CD4 and
CD8 T cell activation.
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gp96 Platform for Infectious Disease
• gp96 platform demonstrated efficacy in multiple infectious diseases
- Significant mucosal protection against simian immunodeficiency virus
(SIV) in monkey
- Induction of Zika-specific CD8 T cells in mouse
- No pathological changes in placenta or fetus
- Elevation of malaria-specific CD8 T cells in mouse
• Multiple grants received to utilize gp96 platform for various
infectious diseases
- National Institute of Health (NIH)
- Department of Defense (DoD)
- Florida Department of Health
• Heat Biologics leverages the body of work done to date to develop
our COVID-19 vaccine program
14
Reference:
Env-spec IgG & IgA Antigen Secreting Cells
(per 10
6 PBMCs)
Induction of Humoral Immune Response
by gp96SIVIg Vaccines
Key Differentiation of gp96 Platform
• Heat’s gp96 platform-based products evaluated in 300+ patients
to date
- HS-110 (Phase 2) demonstrated favorable safety profile and clinical efficacy in
combination with PD-1 inhibitors for treatment of NSCLC
• Potential first-in-class for infectious disease
- Based on human cells engineered to secrete gp96-bound viral antigens
- Platform designed to be antigen-specific and pathogen-specific
- Aim to trigger mucosal immunity by activating both B and T cell responses at the
point of pathogen entry
- Preclinical work using gp96 platform includes SIV/ HIV, malaria and zika
• Heat’s COVID-19 vaccine program focuses on multiple SARS-CoV-2
antigens
- Target to utilize natural immune process to induce long-lasting memory
responses
15
gp96 PLATFORM*
NO ANTI-VECTOR IMMUNITY ?
NO VIRAL ACTIVATION ?
NO INTEGRATION OF FOREIGN DNA
INTO HOST GENOME
ACTIVATION OF T CELLS ?
ACTIVATION OF B CELLS ?
HIGH IMMUNOGENICITY ?
INDUCTION OF MUCOSAL IMMUNITY ?
LONG-TERM MEMORY RESPONSE ?
*Target product profile for infectious disease
Heat Biologics’ COVID-19 Vaccine Program
• Leverages our proprietary gp96
platform to effectively deliver multiple
SARS-CoV-2 antigens to activate the
immune system
• Designed to elicit long-lasting immune
response against SARS-CoV-2 virus
• We plan to collaborate with companies,
researchers, government agencies and
funding organizations to accelerate our
COVID-19 vaccine program
$HTBX
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