Elite Pharmaceuticals Inc (ELTP)

[WeeZuhl]

A few of the major competitors currently working in the global prion disease treatment market are:


Elite Pharmaceuticals Inc

After the isradipine fiasco, I hate to even point out this 10 year old data:

https://www.theatlantic.com/health/archive/2011/10/treatments-for-mad-cow-other-prion-diseases-may-be-coming/246421/

Treatments for Mad Cow, Other Prion Diseases May Be Coming
NEIL WAGNER
OCTOBER 11, 2011


Researchers at NYU have made a key step in developing a treatment for Creutzfeldt-Jakob and a host of other brain-wasting diseases

There are currently no treatments for prion diseases, brain-wasting diseases that are invariably fatal. The most common human prion disease is Creutzfeldt-Jakob disease (CJD), better known as mad cow disease. Researchers at NYU School of Medicine recently took a key step in developing an effective treatment. They found four compounds that significantly delayed disease onset in mice. Because prion diseases are extremely slow to develop, any treatment that delays their initial symptoms long enough could potentially be life saving. And two of these anti-prion compounds are drugs already used to treat other conditions in humans, meaning that clinical trials of them may soon be underway.

The two drugs are trimipramine, an antidepressant, and fluphenazine, an antipsychotic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783831/

Tricyclic antidepressants
Tricyclic antidepressants, like Desipramine, are heterocyclic compounds Figure 2 which have been shown to abolish prion infectivity in cell culture [60] The anti-prion effect was related to the redistribution of cholesterol from the plasma membrane to the intracellular compartment. This leads to membrane destabilization. In this study there were ultra-structural changes in the endosomal compartment. When these authors synthesized a novel compound of quinacrine and desipramine (quinapyramine) it had a synergistic effect in preventing prion infectivity. Of interest, the anti-prion effects of desipramine, quinacrine, quinapyramine were synergistic with simvastatin, a HMG CoA reductase inhibitor.

There is no human data on the effects of tricyclic antidepressants on prion diseases. Caution must be exercised in the use of tricyclic antidepressants as a reversible toxic neurological syndrome resembling prion diseases has been described [61].