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Friday, July 03, 2020 11:20:05 PM
On May 8, NIAID launched the next iteration of its Adaptive COVID-19 Treatment Trial (ACTT 2) by starting a randomized clinical trial to evaluate the combination of remdesivir and Olumiant® (baricitinib)—licensed to Eli Lilly by Incyte—in hospitalized adults with COVID-19. Investigators currently anticipate enrolling more than 1,000 participants, NIAID said.
ACTT 2 is designed to evaluate whether time to recovery is shorter in the combination arm (baricitinib plus remdesivir) compared with remdesivir plus placebo. Recovery is defined as the participant being well enough for hospital discharge, meaning the participant either no longer requires supplemental oxygen or ongoing medical care in the hospital, or is no longer hospitalized (with or without some limitation on activities). Recovery is evaluated up until day 29.
Participants are set to receive a 200mg IV dose of remdesivir, followed by a 100mg once-daily IV dose for the duration of hospitalization up to a 10-day total course of treatment. Baricitinib is being administered as a 4mg oral dose (or crushed and given through a nasogastric tube) up to a 14-day total course of treatment
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