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Re: humble howard post# 84818

Tuesday, 06/16/2020 10:29:53 AM

Tuesday, June 16, 2020 10:29:53 AM

Post# of 232157
Yes, an anti-inflammatory that reduces inflammation. Revolutionary, huh?
The data below sounds like the placebo group in the remdesivir trials.

So, going by the graphic below from the UK "Recovery Trials" website, dexamethasone saved 1/8 of patients on ventilators and 1/25 of patients on oxygen



Dexamethasone reduced deaths by one-third in ventilated patients (rate ratio 0.65 [95% confidence interval 0.48 to 0.88]; p=0.0003) and by one fifth in other patients receiving oxygen only (0.80 [0.67 to 0.96]; p=0.0021). There was no benefit among those patients who did not require respiratory support (1.22 [0.86 to 1.75]; p=0.14).

Based on these results, 1 death would be prevented by treatment of around 8 ventilated patients or around 25 patients requiring oxygen alone.


(emphasis mine)

Read the study yourself:
Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19

Then the "fine print":

https://www.webmd.com/drugs/2/drug-1027-5021/dexamethasone-oral/dexamethasone-oral/details

Side Effects
Stomach upset, headache, dizziness, menstrual changes, trouble sleeping, increased appetite, or weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: signs of infection (e.g., fever, persistent sore throat), bone/joint pain, increased thirst/urination, fast/slow/irregular heartbeat, eye pain/pressure, vision problems, heartburn, puffy face, swelling of the ankles/feet, symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds), pain/redness/swelling of arms/legs, tiredness, mental/mood changes (e.g., depression, mood swings, agitation), unusual hair/skin growth, muscle pain/cramps, weakness, easy bruising/bleeding, slow wound healing, thinning skin, seizures.



(To me it sounds like the first paragraph pretty much sounds like PMS)

Then...

Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aminoglutethimide, birth control pills, certain cancer drugs (dasatinib, lapatinib, sunitinib, aldesleukin), cholestyramine, digoxin, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen), ephedrine, estrogen hormone replacement, isoniazid, mifepristone, rilpivirine, thalidomide.

Other medications can affect the removal of dexamethasone from your body, which may affect how dexamethasone works. Examples include azole antifungals (such as ketoconazole), barbiturates (such as phenobarbital), rifamycins (such as rifampin), certain medications used to treat seizures (such as phenytoin), among others.




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