Sunshine Biopharma Inc (SBFM)

[boomer0921]

United States Patent 10,272,065
Slilaty April 30, 2019
Gem-difluorinated C-glycoside compounds as anti-cancer agents

Abstract
The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.

Inventors: Slilaty; Steve N. (Laval, CA)
Applicant:
Name City State Country Type

ADVANOMICS CORPORATION
Montreal
N/A
CA
Assignee: Benoit & Cote (Montreal, CA)
Family ID: 51166456
Appl. No.: 14/760,021
Filed: January 13, 2014
PCT Filed: January 13, 2014
PCT No.: PCT/CA2014/000029
371(c)(1),(2),(4) Date: July 09, 2015
PCT Pub. No.: WO2014/107803
PCT Pub. Date: July 17, 2014
Prior Publication Data
Document Identifier Publication Date
US 20150353573 A1 Dec 10, 2015
Related U.S. Patent Documents
Application Number Filing Date Patent Number Issue Date
61752075 Jan 14, 2013