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Re: bobshmob post# 83660

Wednesday, 06/10/2020 2:13:12 PM

Wednesday, June 10, 2020 2:13:12 PM

Post# of 233135

Here, the evidence here is very narrowly tailored to viremia in critical covid-19 cases in which there is immunological exhaustion of CD8+. I'd be dang skeptical about generalizing to viruses in throat or nose tissue and to cases where there is no reason to suspect CD8+ exhaustion.



The differential upregulation of CD8+ cells is independent of the level of existing CD8+ cells and is caused by downregulation of calcium signalling.

From the original cancer paper by Dr. Pestell et al.

Additional pathways induced by CCR5, include the PI-30 K pathway and
thereby PDK1 and the serine/threonine kinase protein kinase B (AKT), which in turn induces cell survival, glycolysis, cell proliferation, growth and proliferation of progenitor and stem cells, immune cell differentiation, and the release of eIF4E to promote cap-dependent translation

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