Monday, June 01, 2020 10:07:23 PM
by Josh Smith - Markets Reporter
joshua.smith@themarketherald.com.au
01 June 2020 12:30
https://themarketherald.com.au/mesoblast-asxmsb-reveals-promising-trial-results-for-lung-disease-treatment-2020-06-01/
• Stem cell specialist Mesoblast (MSB) has revealed encouraging results from a Phase II trial of its remestemcel-L product in treating lung disease
• The company was testing the product's ability to treat patients with chronic obstructive pulmonary disease (COPD)
• The trial showed that remestemcel-L was able to bring about improved respiratory and functional outcomes to patients
• Importantly, those treated with the product were able to walk 55 metres further in a six-minute walk test than those who weren't
• Mesoblast is testing the same product for treating patients who develop acute respiratory distress syndrome (ARDS) from COVID-19
• Shares in Mesoblast are currently trading 0.63 per cent lower and worth $3.98 each
Stem cell specialist Mesoblast (MSB) has reported encouraging results from a Phase II trial of its remestemcel-L product in treating lung disease.
Under the trial, 60 patients with chronic obstructive pulmonary disease (COPD) were tested against a placebo control group to monitor the efficacy of remestemcel-L.
COPD refers to a group of lung diseases that all block airflow and make it difficult to breathe. Conditions such as emphysema and chronic bronchitis fall under the COPD umbrella.
Remestemcel-L was proven to bring about "improved respiratory and functional outcomes" to patients tested under the trial.
Stem cell speciality
Mesoblast's product is based on mesenchymal stem cells, or MSCs. These are an adult stem cell generally extracted from bone marrow.
The treatment was initially developed to treat a rare condition known as acute graft-versus-host disease (GVHD) in which the body rejects bone marrow transplants.
The product is already for sale under the brand name Ryoncil in Japan.
In March, Mesoblast told shareholders it would be testing the product against COVID-19 patients with acute respiratory distress syndrome (ARDS) based on its previously-proven ability to treat COPD.
Today, this was further reaffirmed.
Lung improvement
According to Mesoblast, the Phase II trial showed that remestemcel-L significantly improved respiratory and functional clinical outcomes in patients with high levels of C-reactive protein (CRP).
This is a type of protein made by the liver and secreted into the blood and is often the first sign of inflammation or infection in the body.
Mesoblast said significantly higher levels of CRP can result in hospitalisation and even death in patients with COPD. High CRP levels are common with many different types of lung diseases.
Mesoblast's study showed that the greater the degree of inflammation from heightened CRP levels, the better remestemcel-L was at improving lung condition.
Importantly, patients with the highest level of CRP in their bodies were able to walk 55 metres further in a six-minute walk test after being treated with remestemcel-L than those treated with the placebo.
Further, no toxicity or safety concerns were revealed using the treatment.
COVID-19 treatment support
Mesoblast Chief Medical Officer Dr Fred Grossman said today's results provide a "compelling rationale" for the evaluation of a current Phase III trial in the US for treating patients with COVID-19 ARDS.
"The correlation between highest CRP levels and greatest degree of response to remestemcel-L suggests that the inflammatory component of the lung disease may trigger and be amenable to the immunomodulatory effects of treatment with remestemcel-L in patients with acute inflammatory conditions," Dr Fred explained.
"Since recurrent hospitalization rates and mortality in COPD are associated with both high levels of CRP and progressive decline in the six-minute walk test, these results suggest that remestemcel-L could provide longer-term benefits for COPD patients with high levels of inflammation," he said.
Shares in Mesoblast have had a rollercoaster of a day, dancing between red and green several times within the first hour of trade. As at 11:50 am AEST, company shares are down 0.63 per cent and trading for $3.98 each.
Recent MESO News
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 08/29/2024 11:14:45 AM
- Mesoblast Reports Financial Results and Operational Update for Fiscal Year Ended June 30, 2024 • GlobeNewswire Inc. • 08/28/2024 11:27:43 PM
- Mesoblast Financial Results and Corporate Update Webcast • GlobeNewswire Inc. • 08/27/2024 11:25:57 PM
- Appendix 4C Quarterly Activity Report for Quarter Ended June 30, 2024 • GlobeNewswire Inc. • 07/31/2024 01:13:29 AM
- FDA Accepts Mesoblast’s Biologics License Application (BLA) for Ryoncil® in Children With Steroid-Refractory Acute Graft-Versus-Host Disease (SR-aGVHD) • GlobeNewswire Inc. • 07/23/2024 11:53:49 AM
- Patient Enrollment Commenced in Pivotal Phase 3 Trial of Rexlemestrocel-L for Chronic Low Back Pain • GlobeNewswire Inc. • 07/22/2024 12:45:12 AM
- Mesoblast Resubmits Biologics License Application (BLA) with United States Food & Drug Administration (FDA) for Approval of Ryoncil® in Children with Steroid-Refractory Acute Graft-Versus-Host Disease (SR-aGVHD) • GlobeNewswire Inc. • 07/09/2024 12:37:09 AM
- Mesoblast to File Biologics License Application for Ryoncil® FDA Approval Next Week • GlobeNewswire Inc. • 07/01/2024 05:55:36 AM
- Mesoblast Corporate Presentation at Investor Conference • GlobeNewswire Inc. • 06/03/2024 12:23:37 AM
- Appendix 4c Quarterly Activity Report for Quarter Ended March 31, 2024 • GlobeNewswire Inc. • 04/30/2024 01:05:17 AM
- FDA Commentary Sends Biotech Soaring During Premarket Hours • AllPennyStocks.com • 03/26/2024 01:25:00 PM
- United States Food & Drug Administration (FDA) Notifies Mesoblast that Available Clinical Data from Phase 3 Trial Appear Sufficient to Support BLA Submission for Remestemcel-L in Children with Steroid-Refractory Acute Graft Versus Host Disease (SR-aGVHD) • GlobeNewswire Inc. • 03/26/2024 02:34:20 AM
- Mesoblast Successfully Completes Placement and Accelerated Entitlement Offer • GlobeNewswire Inc. • 03/13/2024 11:30:47 PM
- United States Food & Drug Administration (FDA) Supports Accelerated Approval Pathway for Rexlemestrocel-L in End-Stage Heart Failure Patients with a Left Ventricular Assist Device (LVAD) • GlobeNewswire Inc. • 03/10/2024 11:54:12 PM
- Mesoblast Reports Financial Results and Operational Update for Half-Year Ended December 31, 2023 • GlobeNewswire Inc. • 02/28/2024 10:57:09 PM
- Mesoblast Financial Results and Corporate Update Webcast • GlobeNewswire Inc. • 02/26/2024 12:00:00 PM
- United States Food & Drug Administration (FDA) Grants Mesoblast Orphan-Drug Designation for Revascor® (Rexlemestrocel-L) in Children With Congenital Heart Disease • GlobeNewswire Inc. • 02/15/2024 12:46:40 AM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 02/01/2024 02:34:30 AM
- Appendix 4C Quarterly Activity Report for Quarter Ended December 31, 2023 • GlobeNewswire Inc. • 01/31/2024 02:13:34 AM
- Mesoblast Gets FDA's Special Pediatric Designation for Revascor Heart Treatment • Dow Jones News • 01/19/2024 12:28:00 AM
- United States Food & Drug Administration (FDA) Grants Mesoblast Rare Pediatric Disease Designation for Revascor® (Rexlemestrocel-L) in Children With Congenital Heart Disease • GlobeNewswire Inc. • 01/18/2024 11:36:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 01/16/2024 11:33:54 AM
- Form F-6 POS - Post-effective amendments for immediately effective filing • Edgar (US Regulatory) • 01/05/2024 02:57:09 AM
- Form F-6 POS - Post-effective amendments for immediately effective filing • Edgar (US Regulatory) • 12/22/2023 10:13:02 PM
- Mesoblast Files for Orphan Drug and Pediatric Rare Disease Designations for Rexlemestrocel-L as Treatment for Severe Congenital Heart Disease • GlobeNewswire Inc. • 11/26/2023 11:56:21 PM
VHAI - Vocodia Partners with Leading Political Super PACs to Revolutionize Fundraising Efforts • VHAI • Sep 19, 2024 11:48 AM
Dear Cashmere Group Holding Co. AKA Swifty Global Signs Binding Letter of Intent to be Acquired by Signing Day Sports • DRCR • Sep 19, 2024 10:26 AM
HealthLynked Launches Virtual Urgent Care Through Partnership with Lyric Health. • HLYK • Sep 19, 2024 8:00 AM
Element79 Gold Corp. Appoints Kevin Arias as Advisor to the Board of Directors, Strengthening Strategic Leadership • ELMGF • Sep 18, 2024 10:29 AM
Mawson Finland Limited Further Expands the Known Mineralized Zones at Rajapalot: Palokas step-out drills 7 metres @ 9.1 g/t gold & 706 ppm cobalt • MFL • Sep 17, 2024 9:02 AM
PickleJar Announces Integration With OptCulture to Deliver Holistic Fan Experiences at Venue Point of Sale • PKLE • Sep 17, 2024 8:00 AM