Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

That information was published way back and is equally hard to locate now that I don’t have access to a university collection of journals. From what I recall, seems 100ug/ml is at the high end of previous dose ranges and probably enters the area of blood pressure adverse effects. In severe to critical SARS-CoV-2 cases there is already strong evidence that increased pressure against swollen alveoli causes oxygen/co2 transfer to drop. So, I strongly doubt that the highest concentrations will be used in critical care.

All that said, and I’m spitballing here, the safe Brilacidin IV for ABSSSI was .6 and .8 mg/kg body weight, using .6 mg/kg times 62 kg average human, equals ~49 mg/l, or ~49 ug/ml (physics and chem folk I am not accounting for mass and don’t know if I need to). So, like I said 100 ug/ml is about 1.5 times to double a safe total dose. This assumes no adjustment/conversion for vero to human use. Again, all that said, the .6 ml/kg dose was as effective as the .8 mg/kg, and more effective than the double-that (1.2 mg/kg) dose which caused the minor, but concerning, bp side effects.