CV Sciences Inc (CVSI)

[DarthYoda]

Well, to be totally accurate, some of the monkies balls shrunk too. Half kidding but not. Point is, CW's GRAS study didn't show any of this stuff at any dosage level. To what do you attribute the differences between CV's original GRAS study, and CW's GRAS study? Furthermore, what changed in CV's new study that so far makes it sound like it turned out better this time? I haven't read that one yet, but if there are now no problems at the same high dosage levels, then I would want to know how that was achieved:

Macroscopic findings were detected at necropsy in animals that died prematurely at 3000/4000 mg/kg bw/day and included but were not limited to the following: dark red and enlarged liver, yellowish spots on the liver, smaller than normal spleen, seminal vesicles and prostate, dark red lung, dilated stomach, and fluid intestinal content. In surviving animals, the following were detected at necropsy: pale adrenal glands (all dose groups), dark brown liver (2000 and 3000/4000 mg/kg bw/day groups), smaller than normal spleen (one female in the 3000/4000 mg/kg bw/day group), smaller than normal thymus (2000 and 3000/4000 mg/kg bw/day groups), smaller than normal seminal vesicle and prostate (all dose groups), and undernourishment (2000 and 3000/4000 mg/kg bw/day groups). In two male animals at 2000 mg/kg bw/day, the testes were smaller than normal.

Statistically significant, apparently dose-related changes in the absolute and relative weights of liver, thymus, spleen, and adrenal glands at 1000, 2000, or 3000/4000 mg/kg bw/day were noted. Statistically significant absolute and relative changes in various other organ weights were noted in all dose groups. Histological examination of these organs revealed alveolar cytoplasmic vacuolation in the cortical zones of adrenal glands, cytoplasmic vacuolation of hepatocytes in the liver and of proximal convoluted tubules in the kidneys, accelerated involution of thymus, and lymphocyte depletion in the spleen (see Figures 1–3). With regard to the male reproductive system, decreased amounts of (Grade 1) or lack of (Grade 2) secretion in the seminal vesicles or prostate and decreased average diameter of the tubules were observed; additionally, a lack of mature spermatozoa and spermatids was observed in a proportion of seminiferous tubules, indicating decreased intensity of spermatogenesis (Grade 1, 10–20%; Grade 2, 20–50%; Grade 3, 50–60%) in the testes (see Figures 4 and 5). The presence of giant cells was observed.

https://www.hindawi.com/journals/jt/2018/8143582/