Innovation Pharmaceuticals Inc (IPIX)

[Luckytouch]

Please correct me if I am wrong. The BDD drug for UC was designed to be time released into the proximal colon. The colon is to pass waste for excretion and to absorb water back into the body. The BDD drug is expected to act locally and not systemically. Small amounts of drugs can pass thru, and sometimes do, and that is why they test for the systemic absorption. The absorption was minimal which means the drug was locally contained. The BDD drug was coated for time release and passed thru the stomach without effect and was in fact released in the colon as designed. If B is to be delivered orally for systemic absorption then it would be done in the small intestine. The SI is where absorption of nutrients and po meds mostly take place. They evaluate systemic absorption with blood draws and determine absorption from the blood. Doses are varied to reflect the therapeutic level. For this evaluation knowing the effects of gastric contents is important but not so much for coated delivery to the colon. I have not seen any determination of systemic absorption of B via the SI and that would need to be known for development of an oral for systemic use.