ImmunoPrecise Antibodies Ltd (IPA)

[Simbeez]

Candidates: Coronavirus-neutralizing antibodies

Category: ANTIBODY

Type: PolyTope mAb Therapy™, a defined antibody combination designed to target multiple epitopes and mechanisms of viral evasion, and enabled by IPA’s discovery platforms (including B Cell Select™ and DeepDisplay™) and ImmunoPrecise subsidiary Talem Therapeutics’ access to the transgenic animal platform OmniAb® for direct generation of human antibodies.

Status: IPA said March 30 that its collaboration partner EVQLV submitted its first panel of candidate therapeutic antibody sequences, comprised of DNA sequences encoding for potentially therapeutic antibodies against SARS-CoV-2. The sequences were generated in less than one week using computational antibody design, which combines mathematics, statistics, and computer science to identify high-affinity antibodies.

IPA said it will review the antibody candidates, then select approximately 1,200 ideal candidates characterized and screened by EVQLV’s artificial intelligence, and validate the antibody candidates in vitro at IPA’s lab facilities. The companies said they will continue to work on additional panels of computationally generated sequence candidates against SARS-CoV-2.

Earlier last month, IPA announced its PolyTope mAb Therapy approach to developing a COVID-19 treatment. The company also spoke of potentially developing a vaccine for COVID-19, but has not announced any such effort since then.

On February 20, IPA said it designated Ilse Roodink, PhD, chairwoman of Talem’s scientific committee, as its Coronavirus Global Project Leader.

COVID-19: 200 Candidates and Counting
To navigate through the >200 potential therapeutic and vaccine options for COVID-19, GEN has grouped the candidates into four broad categories based on their developmental and (where applicable) clinical progress:

? FRONT RUNNER – the most promising therapeutics/vaccines based on clinical progress, favorable data or both.

? DEFINITELY MAYBE – earlier phases with promising partners, or more advanced candidates in development that have generated uneven data

? KEEPING AN EYE ON… – interesting technology, attracting notable partners, or both, but preliminary data.

? TOO SOON TO TELL – longshots pending additional experimental and/or clinical data.

https://www.genengnews.com/covid-19-candidates/immunoprecise-antibodies-ipa-and-evqlv/