This is certainly far from scientific but if one would want to speculate (like me) and Vertex doesn't come up with a way to reduce dropouts would the following be reasonable guesses: 1) If 950 goes to 12+24 of PEG-ribavirin -> Dropouts 12% (9% + 3%) If 80% of those SVR's come out to 70.4%. 2) If 950 goes to 12+48 of PEG-ribavirin -> Dropouts 18% (9% + another 9% for 36 remaining weeks of PEG). If 85% of those get SVR's that comes out to 69.7% of all treated. 3) If 950 goes to 24+24 of PEG-ribavirin -> Dropouts 30% (18% + 12%) speculate on 90% of those SVR's come out to 63% 4) 950 goes to 24+48 of PEG-ribavirin -> Dropouts 40% (18% + 12%) say 95% SVR that would be 57%.
I would guess 2 the most likely of these which would still leave a lot of room for improvement. Just speculating curious what anyone else would think.
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