The parasites are scared shix. This company will easily trade over $1 and that's 300m mc at a bare minimum before they even initiate PII trial. There's no telling how high this will go when they get the grants and/or fundings. IF the drug is going to be used as prophylaxis and therapeutic, to go with a potential adjuvant with BARDA and JNJ collab vaccine in the discovery stage right now, the mc will push above $1b for those indications. At a minimum, I'll the company trading over $700m.
Anyway, I just checked your inbox messages for the first time today. And I guess, phase II planning - the 10Q answered your question. The second question about the pin popping the balloon analogy, my answer is No. My hypothesis is slightly different from Spike protein and SARsCoV2's cell membrane, which I referred the E -envelope that is a bilayer lipid membrane. In my previous contributions, I mentioned that Bril inhibits viral replications by ENTRY AND REPLICATION; and the MOA of actions will not only involve the virus wall membrane that most think here but it will also include the S-protein. The spike protein of SARScoV2 has always been the mediator of how the virus enters, infect, and induce the pathogenesis into the host cells. So S-protein structure consists of S1 AND S2, for receptor binding and for fusion, respectively, that interfaces with the human ACE2 protein receptor. This S-spike matches up well with Bril since both contain hydrophilic and hydrophobic regions. Bril amphipathic regions simply bind to S-protein. Like-to-like binding affinity molecules between Hydrophobic and hydrophilic. This is remarkable!
What happens next is your positive curvature (convex) change in the physicochemical properties of S-protein binding to Bril. So this distortion of the shape hinders S-protein ability to bind to ACE2 receptor into the host cells. That's your inhibition of antiviral via entry. The last one is inhibition by replication. This the portion where Bril's antimicrobial peptide degenerates, compromises, or melts the bilayer membrane (known as Envelope Protein or E- protein), to make the wall porous and creating a negative curvature that it ultimately inhibits RNA replication. Apoptosis happens!
But we shall see what UNIVERSITY top virologists say!
