Thursday, May 14, 2020 1:30:34 PM
Because it's such a huge opportunity: Covid seems to be right in LDN's wheelhouse in terms of the type of disease for which it should have therapeutic benefits. Covid looks like it's a disease of the nicotinic-cholinergic signalling system. Meaning it attacks the pathways by which the autonomic nervous system and immune system interact to control inflammation:
https://www.sciencedirect.com/science/article/pii/S2214750020302924
https://www.sciencedirect.com/science/article/pii/S1568997220301294
The severe cases happen when uncontrolled cytokine reactions (a type of inflammatory immune response) destroy the body's own tissues. At the same time Covid causes this aspect of the immune response to run amok, it destroys T cells, much like HIV does. So in theory, I think LDN should help both down-regulate the inflammatory cytokines and preserve the number and function of T cells as it does in HIV.
I strongly suspect that the Beaumont trial will be very positive -- that LDN will show the most clear-cut benefit of any drug tested so far. I could be wrong, of course, but we'll soon see.
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