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Re: None

Wednesday, 05/06/2020 9:39:05 AM

Wednesday, May 06, 2020 9:39:05 AM

Post# of 43784
The IDMC meets and sees the unblinded data, and ends trials for futility if the target results cannot be achieved. Given the short time between the last meeting and the news that the last event had finally occurred, we surely must have been down to waiting for one or two events. If those events were to occur in the SOC cadre but not result in the MK + SOC cadre having the at least the 10% better survival, continuing the trial would be futile. That's one or two events out of 298. I'm no statistician, but what's the likelihood that the final event or two occurring in the MK + SOC cadre instead, would then result in what would have been a 10% or greater survival for the MK group over SOC coming in at what, 9 + % ?
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