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Sunday, 04/26/2020 12:30:28 AM

Sunday, April 26, 2020 12:30:28 AM

Post# of 233718
New England Journal of Medicine article and what we can expect Monday.

https://www.nejm.org/doi/full/10.1056/NEJMc2011117

As reported in NEJM on Friday Six severely ill patients received the CCR5 inhibitor leronlimab (PRO 140, CytoDyn) on a compassionate-use basis.

6 levels were very elevated (range, 83 to 8175 pg per milliliter) when leronlimab was initiated (on day 0) in the 5 patients with elevated interleukin-6 levels; these levels decreased markedly 3 days later (range, 37 to 2022 pg per milliliter)

However, only the 1 patient who had the lowest interleukin-6 level (at 83 pg per milliliter) remained in stable condition without intubation.

These are severe cases with underlying conditions..mortality rate is very high...this was only day 3. They seldom survive intubation. I expect Monday we will hear further report on day 7 and further cytokine suppression , stable and on the road to recovery. Very good news.
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