Algernon Pharmaceuticals Inc (AGNPF)

[medchem]

My thoughts on the science!

Thanks for the support. We are in this together. Go back through some of my old posts, I have detailed a lot of the science that backs Ifenprodil. Also the BioPub interviews provide an immense and thorough overview of this company and their goals/trajectory. But hey, you asked for it so let's recap:

1. Pre-clinical research: Ifenprodil has been tested in animal studies by Dr. Mark Williams (the CSO) who found that Ifenprodil and another sister compound which is also patent protected (by Algernon) for respiratory diseases, both outperformed Big Pharma's best drugs for chronic cough and idiopathic pulmonary fibrosis (IPF). So we expect this to become the next drug for chronic cough and IPF after human testing.

2. Safety of Ifenprodil: Ifenprodil has been tested inside and out in many previous studies for the central nervous system and other conditions. Many have been posted by me. The safety profile is well-established. This saves A LOT of money. Hundreds of millions to be more specific. Because we jump right to Phase 2 studies. One of the reasons we chose South korea is the drug is legal there. So we are starting the Phase 2 trial for COVID (see below) at WARP speed.

2. Phase 2 trials for IPF and chronic cough: after receiving these positive results, Dr. Williams brought to the attention of Algernon that he found a postive signal, not only that, but he beat big pharma's best competitor drug. So the next step is Phase 2 trials. Algernon has submitted a clinical trial application in Australia, where we will get 40% rebate on the clinical trial upon completion. Again, saving money. They engaged Novotech, a world leading Contract Research organization to run the trial. That should start later this year. Needs to be approved first. We should hear about that in the coming month or two.

Algernon Pharmaceuticals’ NP-120 (Ifenprodil) Outperforms Merck’s Phase 3 Drug MK-7264 (Gefapixant) in an Acute Cough Study by 110%

3. COVID-19 studies:

Dr. Williams hit the jackpot when he found that Ifenprodil works for severe acute lung injury and acute respiratory distress syndrome (ARDS). This was a study of the most deadly respiratory disease and Ifenprodil reduced the death rate by 50%. Amazing to say the least. Acute respiratory distress syndromes what is killing people who get COVID-19, novel coronavirus.

So whats next...

We are skipping preclinical testing because previous studies have shown are drug is safe. In animal models it greatly reduced mortality from severe viral respiratory disease... just like what we are expecting with COVID.

We have an approved study about to commence in South Korea

Now we have plans for studying in Autralia and Canada. All in humans via Phase 2 trials.

The clinical trial application is submitted in Canada and we are waiting to hear back and we should within the next two weeks.

4. FDA Studies

The americans here would want to know about FDA testing. Safety testing usually cost hundreds of millions. We are using repurposed drugs. We have patents protecting Ifenprodil for respiratory diseases - and it's sister drug. We are saving the hundreds of millions by using the safe drugs.

We have a FDA registered trial We will show it's safe for injection by IV, as well as oral long acting.

5. Support for Clinical trials: We have NOVOTECH which is a certified CRO which is going to be running our trials. We have funding. We have drug ready to go. We are also producing more drug using a certified American chemistry company. We have NOVOTECH investing there own money in Algernon. FDA and medical regulatory authorities in Australia and South Korea and Canada will fast track ifenprofil for COVID-19 related use. Ethics can get approved in days to weeks. Maybe by next week for the South Korea study.

6. Why it works:

Coronaviruses may invade the nervous system and we have a drug that protects the neurons. COVID-19 may invade neurons causing respiratory failure. Coronaviruses invade the nervous system.


An american super computer actually listed Ifenprodil as a target for blocking the infectivity of SARS-COV-2 which causes Coronavirus (we have posted this many times look back through my posts).

Here is proof of invasion of neurons by coronaviruses:

PROOF Coronaviruses infect neurons

Our drug protects them by working on the NMDA receptor.

NMDA receptor

The nervous system invasion by the virus can cause a lot of inflammatory mediators (aka inflammation) to be release and that causes the NMDA receptor to cause neuron injury. This is important because our drug blocks that. Already doctors are publishing work showing covid-19 hurts the nervous system.

And like I said before, HERE IS HOW OUR DRUG WORKS

Coronavirus infection induces increased production of proinflammatory cytokines and neuronal degeneration as a consequence of glutamate excitotoxicity. In physiological conditions, glutamate is mainly synthesized by neurons and released in the synaptic cleft as the primary excitatory neurotransmitter of the CNS that activates the ligand-dependant receptor AMPAr, which allows the entry of sodium ions and the passage of the nerve impulse in the post-synaptic neuron, leading to activation of the NMDA receptor (N-methyl-D-aspartate receptor) that allows the entry of calcium ions. During infection of neurons by coronavirus, cells detect the presence of virus and produce pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) that down-regulate the astrocytic receptor GLT-1 (glutamate transporter 1) and prevent the efficient recapture of glutamate. This situation disturbs the regulation of glutamate homeostasis and theexcess of this neurotransmitter in the synaptic cleft leads to excitotoxicity associated with a massive entry of calcium which eventually leads to degeneration of and death of neuronal cells.


This is why NMDA ANTAGONIST IFENPRODIL is going to be helpful for saving neurons! Ifenprodil works on the NMDA receptor on neurons.


And SARS-COV-2 aka COVID-19 hurts the neurons.

This study shows NMDA receptor plays a role in neuronal cell death.

COVID-19 and the neurons

So Ifenprodil may actually help keep the neurons alive. It might help people from failing to breath.