Cypher Metaverse Inc (fka BKLLF)

[Luckypennyman]

VANCOUVER, BC, CANADA (April 21st, 2020) – Codebase Ventures Inc.


VANCOUVER, BC, CANADA (April 21st, 2020) – Codebase Ventures Inc. ("Codebase" or the
"Company") (CSE: CODE - FSE: C5B – OTCQB: BKLLF), an investment company, is pleased to
expand upon its announcement of April 16th regarding its agreement to acquire a 49% interest in
an arms-length private company with the rights to a provisional patent for a transdermal drug
delivery system for hydroxychloroquine (HCQ) to treat malaria, lupus and rheumatoid arthritis.
Hydroxychloroquine has been heavily publicized in relation to its potential treatment and
prevention role with Covid-19, leading to instances of self medication, where
“hydroxychloroquine can have dangerous side-effects if the dose is not carefully controlled.”1,2
• In oral tablet form, hydroxychloroquine side effects include headache, dizziness, diarrhea,
vomiting, blurred vision, and arrhythmia among others3
• Transdermal delivery of hydroxychloroquine regulates dosage, improving patient
compliance and outcomes4
• Bypassing the GI tract mitigates gastrointestinal side effects
• Transdermal delivery is more efficient, therefore requiring less of the active ingredient to
be administered
The hydroxychloroquine transdermal drug delivery system to be developed by an investee
company of Codebase is designed to control dosage and to deliver the prescribed amount of
the drug over the prescribed time period without inconsistencies inherent in oral tablet delivery
- the premise being that transdermal delivery can reduce and/or eliminate side effects
associated with uncontrolled dosing.
Reformulation Research Laboratories Inc. (RRL), Code’s contract lab partners in the venture,
have provided that transdermal delivery of hydroxychloroquine can result in improved well
being for patients by providing constant drug levels, fewer side effects overall, highlighted by
the fact unlike oral tablets, transdermal delivery bypasses the gastrointestinal tract which can
eliminate side effects from that route such as nausea. In addition, limitations on bioavailability
and metabolism of the active ingredient when taken orally require dosages to be higher than
what is required for therapeutic results. Transdermal delivery is more efficient, and with
2
greater bioavailability and therefore lower amounts of the active ingredient are required, which
also can improve outcomes for patients.
The Company’s scientific expert has read and approved the scientific disclosures contained in the
press release. The Company is not making any express or implied claims that its product has the
ability to eliminate, cure or contain the Covid-19 at this time. RRL is not making any express or
implied claims that any of its products have the ability to deliver hydroxychloroquine through
transdermal at this time.
1 https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30089-8/fulltext
2 https://nationalpost.com/news/politics/canada-quietly-secured-order-for-5-millions-pills-of-anti-malariamedication-eyed-as-potential-covid-19-treatment
3 https://www.healthline.com/health/hydroxychloroquine-oral-tablet
4 https://www.sciencedirect.com/topics/medicine-and-dentistry/transdermal-drug-administration