Sunday, April 19, 2020 6:06:08 PM
"Next, one has to separate the proteins from the silkworm. We don't have to do that with silk because the silk is extruded by the silkworm. No separation necessary. I don't have any idea how hard it would be to separate pharma proteins from the silkworm corpse, but this could be a challenge as well. "
Hard is just a question of cost. If you check out this post I made earlier ( https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151161269 ), for instance monoclonal antibody purification costs 0.2 USD/mg. Which is totally prohibitive for silk, which sells for 0.00005 USD/mg, but negligible cost for antibodies which sell for 200 USD/mg. Again: Producing extremely valuable proteins in silk worms can be a huge business. Companies are not doing that because it is almost impossible to get the GMOs approved for molecular pharming.
"Finally, the proteins that the silkworm is producing and storing in its body fat must be compatible with silkworm growth and reproduction. Might the proteins be toxic to silkworms? "
Most likely some will be. Others not. Producing the ones compatible with silkworm metabolism would still be a huge business.
"
For all these reasons, I consider the possibility of drug production in silkworms to be more of an unproven possibility and less than a sure bet,"
For all these reasons I consider molecular pharming a pretty feasible way to grab some quick cash. Most likely they can produce antibodies, which have the largest market share as therapeutic agents. And they sell for a lot more than silk.
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